What kind of antidepressant is trazodone

what kind of antidepressant is trazodone

[Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]

The pharmacological properties and possible clinical use of trazodon in the treatment of depression are presented. Trazodon is the only antidepressant from the SARI (Serotonin Antagonists and Reuptake Inhibitors) group available in Poland. It has a wide pharmacodynamic profile (being an antagonist o . Apr 27, Trazodone is an antidepressant drug that belongs to the serotonin antagonist and reuptake inhibitor (SARI) class of medications. It is chemically unrelated to other known antidepressant agents such as tricylcic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRIs).

A small number what kind of antidepressant is trazodone children, teenagers, and young adults up to 24 years of age who took antidepressants 'mood elevators' such as trazodone during clinical studies became suicidal thinking about harming or killing oneself or planning or trying to do so.

Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants how to do a journal critique treat these conditions. However, experts are not sure about how great this driver alertness course what to expect is and how much it should be considered in deciding whether a child or teenager should take an antidepressant.

Children younger than 18 years of age should not normally take trazodone, but in some cases, a doctor may decide that trazodone is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take trazodone or other antidepressants even if you are an adult over age You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased.

You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement.

Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking trazodone, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet Medication Guide when you begin treatment with trazodone.

Read the information carefully and ask your doctor or pharmacist if you have any questions. No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk what kind of antidepressant is trazodone you will become suicidal.

This risk is higher if you or anyone in your family has or has ever had bipolar disorder mood that changes from depressed to abnormally excited or mania frenzied, abnormally excited mood or has thought about or attempted suicide.

Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators.

It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance. Trazodone comes as a tablet and as an extended-release long-lasting tablet to take by mouth. The tablet is usually taken with a meal or light snack two or more times a day. The extended-release tablet is usually taken once a day at bedtime on an empty stomach, either one hour before or two hours after a meal. To help you remember to take trazodone, take it around the same time every day.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trazodone exactly as directed.

Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor. Swallow the extended-release tablets whole or broken in half on the score mark; do not chew or crush them. Your doctor may start you on a low dose of trazodone and gradually increase your dose, not more than once every 3 to 4 days.

Your doctor may decrease your dose once your condition is controlled. Trazodone controls depression, but does not cure it. It may take 2 weeks or longer before you feel the full benefit of trazodone. Continue to take trazodone even if you feel well. Do not stop taking trazodone without talking to your doctor. If you suddenly stop taking trazodone, you may experience withdrawal symptoms such as anxiety, agitation, or difficulty falling asleep or staying asleep.

Your doctor will probably decrease your dose gradually. Trazodone is also sometimes used to treat insomnia and schizophrenia a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions ; anxiety excessive worry.

Trazodone is also sometimes used to control abnormal, uncontrollable movements that may be experienced as side effects of other medications. Talk to your doctor about the possible risks of using this medication for your condition. This medication may be prescribed for other uses. Ask your what kind of antidepressant is trazodone or pharmacist for more information. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

Take the missed dose as soon as you remember it. However, if it is how to keep car ramps from sliding time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Trazodone can cause painful, long lasting erections in males.

Talk to your doctor about the risk of taking trazodone. Trazodone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture not in the bathroom. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach.

In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Do not let anyone else take your medication.

Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Generic alternatives may be available. Trazodone pronounced as traz' oh done. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow?

What special dietary instructions should I follow? What what can cause a brain hemorrhage I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication?

Brand names. Other uses for this medicine. What special precautions should I follow? Before taking trazodone, tell your doctor and pharmacist if you are allergic to trazodone or any other medications. Be sure to mention any of the following: anticoagulants 'blood thinners' such as warfarin Coumadin ; antidepressants; antifungals such as ketoconazole Nizoralitraconazole Sporanoxor voriconazole Vfend ; aspirin and other NSAIDs such as ibuprofen Advil, Motrin and naproxen Aleve, Naprosyn ; certain medications for human immunodeficiency how to use a gyroscope HIV or acquired immunodeficiency syndrome AIDS such as atazanavir Reyatazindinavir Crixivannelfinavir Viraceptritonavir Norvir, in Kaletraand saquinavir Invirase ; cimetidine Tagamet ; cisapride Propulsid ; clarithromycin Biaxin, in Prevpac ; cyclosporine Neoral, Sandimmune ; danazol Danocrine ; delavirdine Rescriptor ; dexamethasone Decadron ; digoxin Digitek, Lanoxin, Lanoxicaps ; diltiazem Cardizem, Dilacor, Tiazac ; diuretics; disopyramide Norpace ; dofetilide Tikosyn ; erythromycin E.

Also, tell your doctor or pharmacist if you are taking the how to hard boil perfect easter eggs medications, called MAO inhibitors, or if you have stopped taking them within the past 2 weeks: isocarboxazid Marplanphenelzine Nardilselegiline Eldepryl, Emsam, Zelaparor tranylcypromine Parnate. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Also tell your doctor if you have or have ever had high blood pressure, sickle cell anemia a disease of the red blood cellsmultiple myeloma cancer of the plasma cellsleukemia cancer of the white blood cells cavernosal fibrosis, Peyronie's disease a condition that affects the shape of the penis such as angulationor heart, liver or kidney disease.

Trazodone may cause QT prolongation an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death. Tell your doctor if you or anyone in your family has or has ever had long QT syndrome an inherited condition in which a person is more likely to have QT prolongation or if you have or have ever had low levels of potassium or magnesium in your blood or an irregular heartbeat.

If you become pregnant while taking trazodone, call your doctor. Do not drive a car or operate machinery until you know how this medication affects you. Alcohol can make the side effects from trazodone worse. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Talk to your doctor about having an eye examination before you start taking this medication.

If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away. Trazodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache nausea vomiting bad taste in mouth diarrhea constipation changes in appetite or weight weakness or tiredness nervousness dizziness or lightheadedness feeling unsteady when walking decreased ability to concentrate or remember things confusion nightmares muscle pain dry mouth rash sweating changes in sexual desire or ability uncontrollable shaking of a part of the body numbness, burning, or tingling in the arms, legs, hands, or feet decreased coordination tired, red, or itchy eyes ringing in ears Some side effects can be serious.

Symptoms of overdose may include: vomiting drowsiness changes in heartbeat seizures difficulty breathing painful erection that does not go away. What other information should I know? Keep all appointments with your doctor. Browse Drugs and Medicines.

Publication types

Desyrel (trazodone): It is the brand name for trazodone, an antidepressant which is mainly used to help people sleep. Only doses above mg has antidepressant effects but that would usually cause so much sleepiness that it is not used at all for depression. Most people sleep well at mg or below. Feb 04, Trazodones effectiveness as an antidepressant is generally more pronounced at doses of mg to mg. 4 These drugs may have an immediate effect on insomnia and anxiety but may take weeks to have an effect on depression. 5,6. Trazodone for pain is also a frequent off-label use of the drug, and in particular, it can be useful for chronic pain. In many cases, people who have chronic pain are given antidepressants along with medications that control the pain itself, and this is because of the effects chronic pain can have on mood and the likelihood of developing depression.

The pharmacological properties and possible clinical use of trazodon in the treatment of depression are presented.

It has a wide pharmacodynamic profile being an antagonist of 5-HT2A and 5-HT2C serotoninergic receptors, alpha1 and alpha2 adrenergic receptors as well as H1 histaminergic receptors, and in higher doses it blocks the SERT serotonine transporter which explains its wide therapeutic spectrum ranging from symptomatic treatment, through the potentialization of other drugs activity, all the way to monotherapy of depressive syndromes.

An especially complex action on the serotoninergic system results in the lack of unwanted side-effects during treatment with trazodon e. This requires its dose to be adjusted when administered simultaneously with other drugs influencing the activity of those isoenzymes. Trazodon CR is an orally administered controlled release form, which simplifies its dosage and reduces the risk of adverse effects. Usually doses of 75 to mg daily are used; in the elderly those doses should be lower.

Trazodon turned out to be effective in the treatment of various depressive syndromes, amongst them depression with insomnia, with anxiety and unrest, as well as depression in the elderly. In the recommended dose spectrum, trazodon is well tolerated. Unwanted adverse effects of the drug appear rarely and they are: somnolence, dizziness, gastrointestinal dysfunctions, and dry mouth.

Abstract The pharmacological properties and possible clinical use of trazodon in the treatment of depression are presented. Publication types English Abstract Review.

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